(KLZA)-- An early Thanksgiving morning wreck on Highway 2 west of Unadilla involved a vehicle traveling the wrong way on the 4-lane highway for the second time in a week.

The Otoe County Sheriff's Office reports the a 17-year-old male from Tecumseh was driving a pickup west in the eastbound lane of traffic and collided head-on with a semi-truck.

The teenager was flown from the scene of the crash by medical helicopter to a Lincoln hospital with what were described as serious injuries.

The 66-year-old driver of the semi is from Ohio and was transported to the hospital in Syracuse while a passenger in his truck, a 70-year-od man from Indiana was transported to a Lincoln hospital by ambulance.

The crash remains under investigation.

The Nebraska State Patrol and fire and rescue units from Unadilla and Syracuse responded to the wreck that occurred shortly before 6 a.m.

The names of those injured have not been released.